Antimycic Acid and its Acetyl Derivative from Deep-sea-derived <i>Alcanivorax</i> sp. SHA4 with Neuroprotective Properties
نویسندگان
چکیده
Chemical investigation of secondary metabolites the deep-sea-derived Alcanivorax sp. SHA4 identified a new compound 1 which was antimycic acid (2)'s acetyl derivative, and 11 known compounds (2-12). Their structures were elucidated by extensive nuclear magnetic resonance mass spectrometry spectroscopic analyses, absolute configuration determined Marfey's method. Bioactivity assays indicated that 2 exhibited significant neuroprotective properties against glutamate-induced PC12 cell death in 0.02-0.31 μM.
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2023
ISSN: ['1555-9475', '1934-578X']
DOI: https://doi.org/10.1177/1934578x221110661